2016 Fiscal Year Final Research Report
Tumor suppression mechanism through anti-inflammation and anit-fibrosis in non-small cell lung cancer
| Project/Area Number |
26462129
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 非小細胞肺癌 / 抗炎症 / 抗線維化 / 肺癌悪性度 |
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| Outline of Final Research Achievements |
(1)Analysis of inflammatory cytokines and malignant grade of lung cnacer was done.(Results) VEGF（p=0.047）、Fibronectin（p=0.011) and HGF（p=0.02) mRNA expression were significantly associated with intratumoral vessel invasion.
(2)Multicytokines analysis of IP or non-IP NSCLC was performed. (Results) ①In NSCLC without IP, IL-6 mRNA expression in non-cancerous lesion was significantly higher than that in cancerous lesion. In addition, VEGF mRNA expression in cancerous lesion was significantly higher. ②In NSCLC with IP, IL-6 mRNA expression in non-cancerous lesion was also significantly higher. On the other hand, IL-1β,VEGF and FGF mRNA expression in cancerous lesion were significantly higher, respectively. ③FGF mRNA expression both in cancerous and non-cancerous lesion with IP, was significantly higher than that with non-IP.
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| Free Research Field |
呼吸器外科学
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