Estrogen concentration in peripheral lung of Synchronous multiple lung adenocarcinomas

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462131
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Kumamoto University
• Principal Investigator: Shiraishi Kenji 熊本大学, 大学院生命科学研究部(医), 助教 (70363538)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 多発肺腺癌 / エストロゲン

Outline of Final Research Achievements

In this study, we quantitated estrogen concentration in the peripheral lungs of postmenopausal female patients with synchronous multiple lung adenocarcinomas SMLA.　The tissue concentration of estrogens (estrone [E1] and estdadiol [E2]) in the noncancerous peripheral lung were measured with liquid chromatography/electrospray tandem mass spectrometry in postmenopausal female patients with lung adenocarcinoma. The concentrations of E1 and E2 in the noncancerous tissue were significantly higher in SMLA cases than control cases. The minor allele (A) of single nucleotide polymorphism rs3764221 were significantly associated with higher concentration of E1 and E2 and higher CYP19A1 mRNA expression.
The tissue estrogen concentration of peripheral lung was significantly higher in SMLA than control cases. The high concentration of estrogen may be one of the causes of multicentric development of peripheral lung adenocarcinomas.

Free Research Field

呼吸器外科