2016 Fiscal Year Final Research Report
The roles of cancer stem cells and driver genes for clarifying the mechanism of lung cancer from COPD
| Project/Area Number |
26462139
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
SEKINE YASUO 東京女子医科大学, 医学部, 教授 (70312957)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 肺癌 / 扁平上皮癌 / 遺伝子多型 / PD-L1 |
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| Outline of Final Research Achievements |
It has been reported that squamous cell carcinoma (SCC) has many polymorphisms and that expression of PD-L1 is frequently observed. SCC is highly observed in patients with COPD. We investigated the relationship between SCC and many types of cancer-related genes by immunohistochemistry (IHC). IHC (p65, PTEN, p16, PI3K, FGFR1) has been done for 50 cases of SCC. SCC patients with COPD (25 cases) tended to express PTEN and FGFR1 more strongly than non-COPD patients. Currently we investigate expression of PD-L1 for SCC.
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| Free Research Field |
肺癌
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