Novel treatment for refractory dural arteriovenous fistula: Therapeutic effect of bevacizumab

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462152
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: University of Toyama
• Principal Investigator: AKIOKA Naoki 富山大学, 附属病院, 助教 (70422631)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 脳血管障害学 / 硬膜動静脈瘻 / ベバシズマブ

Outline of Final Research Achievements

To establish the animal model of dural arteriovenous fistula, mouse model of chronic cerebral ischemia was created by common carotid artery stenosis using external microcoils with inner diameter of 0.2 mm or less. The changes of cerebral blood flow in the cerebral cortex were measured by laser-Doppler flowmetry for 30 days after common carotid artery stenosis. The CBF values decreased to about 35% immediately after carotid stenosis, however, the CBF recovered to about 70% of baseline at 30 days. Histological analysis revealed selective detachment of neurons at the hippocampal CA1 region and myelin degeneration at the white matter of corpus callosum.

Free Research Field

脳神経外科学