Changes in BBB functions and accumulation of amyloid beta in chronic cerebral hypoperfusion

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462204
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Osaka University
• Principal Investigator: Kato Hiroki 大阪大学, 医学系研究科, 講師 (20448054)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: PET / SPECT

Outline of Final Research Achievements

Cerebral hypoperfusion rat model by occlusion of bilateral common carotid arteries is a representative animal model for investigation of chronic cerebral hypoperfusion. Cerebral metabolic rate of oxygen in relation to cerebral blood flow (CBF) and cerebral blood volume has not yet been clarified in the animal models. We clarified cerebral perfusion and oxygen metabolism in the cerebral hypoperfusion rat model in the acute and the chronic phases under anesthesia by O-15 PET based on steady-state method.
SPECT is one of the important modalities for evaluation of CBF in the patients with cerebral hypoperfusion. We clarified CT-based reconstruction method by using recently developed integrated SPECT/CT significantly improved detectability of CBF reduction in the patients.

Free Research Field

核医学