2016 Fiscal Year Final Research Report
Dose inflammatory cytokines work as biomarkers of epileptic seizure?
| Project/Area Number |
26462207
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | てんかん / バイオマーカー / 炎症性サイトカイン / 髄液 / 血液 |
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| Outline of Final Research Achievements |
The diagnosis of epilepsy depends on their subjective symptoms, electroencephalogram, and imaging, but it is difficult to follow up objectively their changes over time. Clinical observation mostly depends on only the complaints of patients and families. We hypothesized that High Mobility Group Box 1 (HMBG1), an inflammatory protein, would become an objective biochemical biomarker related to epileptic seizures. HMBG1 Concentration in plasma of epileptic patients showed no significant change related to partial seizure and HMBG1 concentration in cerebrospinal fluid (CSF) was less than sensitivity. On the other hand, in the rat epilepsy models, significant increase in HMBG1 concentration in the CSF was observed on the second day after the epileptic seizure. These results indicate that HMBG1 in the CSF have potential to become a biomarker of epileptic seizures, depending on seizure type and its frequency.
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| Free Research Field |
脳神経外科学
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