The effect of corpus callosal stimulation on epileptic cortical hyperexcitability

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462208
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Osaka University
• Principal Investigator: Satoru Oshino 大阪大学, 医学系研究科, 助教 (40403050)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 機能脳神経外科 / てんかん

Outline of Final Research Achievements

Corpus callosum is the largest bundle of white matter and which consists of mainly inhibitory fiber. We studied whether there were some inhibitory effects of corpus callosum stimulation on epileptic cortical hyper-excitability. Using cat model under general anesthesia, we recorded "Penicillin induced epileptic discharge" and its change under the stimulation of corpus callosum. As a result, we could not find certain inhibitory change on the epileptic discharge. Conversely, the epileptic discharge was increased by stimulation in some of the cases, although the parameters of stimulation were varied. These results indicates that corpus callosum stimulation has certain impact on cortical excitability, but electrical stimulation with the parameters we have attempted does not induced its physiological inhibitory effect. This interesting findings lead us to apply this model to new research, which investigates epileptic propagation through white matter.

Free Research Field

脳神経外科