2016 Fiscal Year Final Research Report
Development of a new treatment method of intractable fractures using carbon dioxide
| Project/Area Number |
26462266
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kobe University |
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Principal Investigator |
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| Research Collaborator |
KUROIWA Yu
ARAKURA Michio
TAKAHARA Syunsuke
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 骨折治癒促進 |
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| Outline of Final Research Achievements |
We conducted an animal study as a pre-clinical trial to develop a new treatment method of an intractable fractures. Bone defect was created in the rat femoral shaft and stabilized with external fixator. After the surgery to create bone defect model, the healing process was compared between a group with transcutaneous carbon dioxide absorption and a control group without it. Bone healing was assessed radiographically and histologically. The bone mineral density of the newly formed bone was measured. The mechanical properties of the excised femurs were assessed. We found that bone healing was accelerated through an acceleration of endochondral ossification by the transcutaneous carbon dioxide absorption. Our results suggested that the transcutaneous carbon dioxide absorption could be a beneficial treatment option of intractable fractures.
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| Free Research Field |
骨折治癒促進
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