2016 Fiscal Year Final Research Report
Development of stump treatment method using heat shock protein inhibition technique for sarcoma
| Project/Area Number |
26462273
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Terauchi Ryu 京都府立医科大学, 医学(系)研究科(研究院), 講師 (20575154)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 骨肉腫 / heat shock protein 70 / 化学療法 / シスプラチン / アポトーシス |
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| Outline of Final Research Achievements |
Heat shock protein 70 (Hsp70) is expressed at high levels in cancer cells and attenuates the therapeutic efficacy of anticancer agents, resulting in a poorer prognosis. The objective of this study was to investigate if inhibition of Hsp70 expression in cultured osteosarcoma cells might enhance sensitivity of the cells to cisplatin.When cisplatin was administered under the inhibitory condition of Hsp70, the antitumor effect of cisplatin was significantly enhanced.This result suggested that suppression of Hsp70 could be a new adjuvant therapy for chemotherapy for osteosarcoma.
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| Free Research Field |
骨軟部腫瘍学
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