Gliostatin as a novel therapeutic target for rheumatoid arthritis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462309
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Nagoya City University
• Principal Investigator: NAGAYA Yuko 名古屋市立大学, 大学院医学研究科, 教授 (90291583)
• Research Collaborator: KAWAGUCHI Yohei 名古屋市立大学, 大学院医学研究科, 臨床研究医 (90766734) ; OGURI Yusuke 名古屋市立大学, 大学院医学研究科, 臨床研究医 (80528969) ; TATEMATSU Naoe 名古屋市立大学, 大学院医学研究科, 大学院生
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 関節リウマチ / 滑膜細胞 / グリオスタチン / チミジンホスホリラーゼ / マトリックスメタロプロテアーゼ

Outline of Final Research Achievements

Treatment of rheumatoid arthritis (RA) has advanced dramatically in the last decade, and it has become possible to aim for remission through strong treatment intervention such as biological and targeted anti-rheumatic drugs. However, there are drug-resistant patients who do not respond to any drug treatment. We have reported for the first time that gliostatin is closely involved in the pathogenesis of RA. In this study, we clarified that this gliostatin can be therapeutically targeted. The mechanism of joint destruction by gliostatin and its suppression mechanism were analyzed by molecular biological method using fibroblast-like synoviocytes derived from patients with RA

Free Research Field

整形外科