2016 Fiscal Year Final Research Report
Neuroprotective effect of vitamin E derivatives: a spin resonance study
| Project/Area Number |
26462340
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology
|
|---|
| Research Institution | Oita University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 虚血再灌流傷害 / 脳エネルギー代謝 / 抗酸化能 / フリーラジカル消去能 / ビタミンＥ誘導体 / 核磁気共鳴 / 電子スピン共鳴 / スピン共鳴解析 |
|---|
| Outline of Final Research Achievements |
It has been known that vitamin E derivatives (ETSGS, EPCK1) are neuroprotective against ischemia-reperfusion injury (IRI). In the present project, 31P-nuclear magnetic resonance spectroscopy revealed that the recovery of the energy status in the rat brain slices after IRI was significantly better with the addition of the vitamin E derivatives. Direct free radical scavenging capacity of the derivatives were also demonstrated against multiple free radical species including hydroxyl radical, superoxide anion and nitric oxide by using electron spin resonance spectroscopy. It was suggested that the possible neuroprotective mechanisms of the vitamin E derivatives include direct radical scavenging capacity against multiple free radical species.
|
| Free Research Field |
医歯薬学
|
