2017 Fiscal Year Final Research Report
The search for novel analgesics based on pain control with aromatase and GPR30
Project/Area Number |
26462387
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Anesthesiology
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Research Institution | National Center for Global Health and Medicine (2016-2017) National Cancer Center Japan (2014-2015) |
Principal Investigator |
Shiraishi Seiji 国立研究開発法人国立国際医療研究センター, その他部局等, 医師 (90216177)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Keywords | GPR30 / aromatase / ovariectomy / miRNA |
Outline of Final Research Achievements |
Aromatase inhibitor(Letrozole,1 or 5 mg/kg) reduced threshold value of pain for a Formalin test, neuropathic pain (Seltzer model) and a cancer bone metastases pain model. G-protein-coupled estrogen receptor, GPR30 inhibitor (G15) of the cell membrane localization increased threshold value of pain for each animal models. We examined a manifestation immunohistochemically change of GPR30 and aromatase in the spinal cord in a neuropathic pain and a cancer pain mode rats. Athreshold value of pain decrease with the aromatase inhibitor administration less had the significant difference with the ovariectomy rat as a post-menopausal model. Using each spine fusion graft, we compared the microglial activation by the IBa1 immunostaining and examined association with the pain as compared with a control in each miRNA.
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Free Research Field |
疼痛学
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