Prediction of cancer metastasis by tumor endothelial secreting proteins

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462390
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Hokkaido University
• Principal Investigator: Shinohara Nobuo 北海道大学, 医学研究科, 教授 (90250422)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 腫瘍血管新生 / biglycan / 転移 / 腫瘍血管内皮

Outline of Final Research Achievements

In this study, we addressed the involvement of tumor endothelial secreting molecule in cancer metastasis. Among these molecules, we focused on biglycan and analyzed the role of biglycan in cancer metastatic potential. We observed that biglycan-secreted from tumor endothelial cells activate NF-B and ERK in cancer cells and attract cancer cells towards tumor blood vessels, resulting in increase of lung metastasis. Furthermore, blood level of biglycan in cancer patients correlated with vascular invasion of cancer. These suggested that tumor endothelial secreting factor may be biomarker in cancer metastasis.

Free Research Field

泌尿器科学