2016 Fiscal Year Final Research Report
Functional analysis of FAM110 gene family in the prostate cancer
| Project/Area Number |
26462395
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Akita University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 前立腺癌 / 細胞増殖 |
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| Outline of Final Research Achievements |
In the functional analysis of FAM110 gene family (FAM110A, B and C), we found that cell invasiveness was increased in FAM110A stable expressed cancer cell line and cell proliferation was suppressed in FAM110C stable expressed cancer cell line although these mechanisms were still unknown. In the FAM110A transient transfected prostate cancer cell line, N-cadherin mRNA expression level was increased, on the other hand, this expression level was suppressed in the FAM110C transient transfected prostate cancer cell line. These results suggested that there was an inverse relationship between the functions of FAM110A and FAM110C. Additionally, FAM110C transient transfected cell line showed suppression of cell proliferation. These results suggested FAM110C gene play a role in tumor suppression.
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| Free Research Field |
前立腺癌
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