Role of the chromatin regulating genes in the progression of renal cell carcinoma

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462402
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: The University of Tokyo
• Principal Investigator: Kume Haruki 東京大学, 医学部附属病院, 登録診療員 (10272577)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 腎細胞癌 / クロマチン制御遺伝子 / 癌の進展

Outline of Final Research Achievements

To investigate the role of the chromatin regulating genes in the progression of renal cell carcinoma (RCC) including PBRM1 gene, BAP1 gene, SETD2 gene, which have been shown to be frequently mutated, firstly we analyzed cases with small RCC (=< 4cm). Multivariate analysis showed that hyperploid tumor was the only predictive factor. However, there was no relation between hyperploid tumor and mutation of chromatin regulating genes. Then we analyzed metastatic cases. The progression free survival was similar in cases with and without mutation of chromatin regulating genes.
In conclusion, the chromatin regulating genes may play only a minor role in the progression of RCC.

Free Research Field

泌尿器癌