2016 Fiscal Year Final Research Report
Establishment of a novel therapeutic strategy for castration-refractory prostate cancer targeting ubiquitin-proteasome system
| Project/Area Number |
26462406
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 去勢抵抗性前立腺癌 / 再燃メカニズム / ユビキチン-プロテアソーム系 / NF-κB / 小胞体ストレス / UPR / シグナル伝達 / クロストーク |
|---|
| Outline of Final Research Achievements |
Elucidating a comprehensive mechanism through which most patients with advanced prostate cancer have an initial response to androgen deprivation therapy, but eventually progress to a castration-resistant state is critical to establish a novel treatment strategy for castration refractory prostate cancer (CRPC). We investigated the mechanism for the emersion of CRPC from the perspective of ubiquitin-proteasome system regulating both NF-kappa B and unfolded protein response (UPR) activation. Our study suggested that constitutive NF-kappa B activation and successive escape from endoplasmic reticulum stress might be one of mechanism for CRPC emersion, and that trying development of new drugs with targeting for ubiquitin-proteasome system might be a novel therapeutic strategy for the management of CRPC.
|
| Free Research Field |
腫瘍学
|
