2016 Fiscal Year Final Research Report
Search for therapeutic targets from novel prognostic-related genes based on comprehensive gene expression analysis of kidney cancer
| Project/Area Number |
26462418
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 腎癌の予後予測 / 腎癌の網羅的遺伝子発現解析 / 38遺伝子セット |
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| Outline of Final Research Achievements |
Progressive renal cell carcinoma is a urological cancer that has a high mortality rate and is difficult to treat. Since it shows diversity in the clinical course, there is a need for a method to predict the outcome of prognosis and therapeutic drugs. In this study, comprehensive gene expression analysis was performed on clear cell renal cell carcinoma, which accounts for more than 80% of kidney cancer. We confirmed that the classification in the gene expression profile strongly correlated with disease prognosis of clear cell renal cell carcinoma. Furthermore, it was suggested that clinically clear cell renal cell carcinoma has a difference in the therapeutic effect of targeted therapy in each of three subgroups based on the expression of 38 genes. From these results, it was suggested that this classification could be applied to clinical prognostic predictions and therapeutic drug selection.
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| Free Research Field |
泌尿器癌
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