Tissue engineering for lower urinary tract using autologous bone marrow or fatty tissue derived stem cells.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462441
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Shinshu University
• Principal Investigator: ISHIZUKA Osamu 信州大学, 学術研究院医学系, 教授 (20184541)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 再生医療 / 膀胱 / 尿道括約筋 / 骨髄幹細胞 / 脂肪幹細胞

Outline of Final Research Achievements

We could culture and proliferate the bone-marrow-derived mesenchymal stem cells derived from the femur of rabbit, or fatty-tissue derived stem cells to stem cell sheets. The cultured stem cell sheet were implanted into the radiation injured bladder or cryo-injured urethral sphincter, and we could found the reconstruction of the bladder and urethral sphincter by immuno-histological methods and functional study. This fact means stem cells sheet is more effetive for tissue engineering of lower urinary tract than simple stem cell injection methods.

Free Research Field

泌尿器科学