The development of a rat model of bladder underactivity induced by chronic bladder ischemia

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462454
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: National Center for Geriatrics and Gerontology (2016); Nihon University (2014-2015)
• Principal Investigator: NOMIYA Masanori 国立研究開発法人国立長寿医療研究センター, 泌尿器外科, 医長 (00398348)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 低活動膀胱 / 膀胱虚血

Outline of Final Research Achievements

We developed a rat model of bladder underactivity induced by chronic bladder ischemia. A prominent finding in this model is that bladder overactivity was observed in the relatively early period, whereas bladder underactivity was found in the late period. Chronic bladder ischemia and repeated ischemia / reperfusion produce oxidative stress in the bladder, leading to denervation of the bladder and expression of tissue damaging molecules in the bladder wall. This may contribute to the development of bladder overactivity progressing to bladder underactivity. Our findings suggest that prolonged bladder ischemia may cause bladder dysfunction, which develops from bladder overactivity to bladder underactivity.

Free Research Field

排尿障害