Regulation of acquirement of invasiveness in placental trophoblasts by galectin family

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462502
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Kanazawa Medical University
• Principal Investigator: SHOJI Hiroki 金沢医科大学, 一般教育機構, 教授 (10263873)
• Research Collaborator: HATTA Toshihisa 金沢医科大学, 医学部, 教授 (20238025)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ガレクチン / 胎盤 / 栄養膜細胞 / 浸潤 / オートファジー

Outline of Final Research Achievements

Galectins bind beta-galactoside, and have been shown to regulate immune-system and tumor invasion etc. We have previously shown that galectin 4 possibly has roles in regulation of acquirement of invasiveness in rat placental trophoblast cell line (Rcho-1). Expression of galactin 4 is specifically down regulated during the differentiation of Rcho-1 cells. In the present study, we have shown that galactin 4 may regulate cell-cell adhesion in Rcho-1 cells. Also, we have shown that autophagy may play important roles both in down-regulation of galactin 4 expression and in the acquirement of invasiveness. The results of present study suggested that Galectins and autophagy have important roles in regulation of acquirement of invasiveness in placental trophoblasts.

Free Research Field

分子生物学，生化学，発生生物学