2016 Fiscal Year Final Research Report
A functional analysis of a transcription factor Hand2 and its clinical significance in the human endometrium
| Project/Area Number |
26462505
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KANZAKI Hideharu 関西医科大学, 医学部, 教授 (80135566)
NISHIGAKI Akemi 関西医科大学, 医学部, 研究員 (10724180)
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| Research Collaborator |
TSUZUKI Tomoko
SHINDOH Hisayuu
MURATA Hiromi
KIDA Naoko
KOBAYASHI Maiko
KIDO Takeharu
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 生殖医学 |
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| Outline of Final Research Achievements |
The human uterine endometrium undergoes cyclic proliferation and differentiation controlled by the female sex hormones during the menstrual cycle. Decidualization of the human uterine endometrium involves the dramatic morphological and functional differentiation of the human endometrial stromal cells (ESCs) and is an essential preparative event for the successful establishment of pregnancy. This process occurs in the human endometrium in response to progestin. We investigated whether heart and neural crest derivatives expressed transcript 2 (HAND2) regulates during decidualization of human ESCs. Progestin induced HAND2 mRNA levels in ESCs in a time- and dose-dependent manner. Silencing of HAND2 expression significantly reduced decidualization marker. These results suggest that HAND2 plays a key role in the regulation of progestin-induced decidualization of human ESCs.
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| Free Research Field |
産婦人科
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