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2016 Fiscal Year Final Research Report

Mechanism of inhibitory effect of Carbonyl reductase on cancers aiming to gene therapy

Research Project

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Project/Area Number 26462508
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionHirosaki University

Principal Investigator

Yokoyama Yoshihito  弘前大学, 医学研究科, 教授 (90261453)

Project Period (FY) 2014-04-01 – 2017-03-31
KeywordsCarbonyl reductase / Ovarian cancer / アポトーシス / 腫瘍縮小 / 遺伝子治療
Outline of Final Research Achievements

Tumor growth was significantly suppressed in mice injected with CR1-overexpressing cells. Tumor volume in the CR1 induction group decreased temporarily until 2 weeks. Tumor cell membranes in both CR1 induction and control groups were positive for TNFR1 expression; however, total protein levels did not differ between the two groups. TNFR-2 expression was comparatively weak in both groups. The expression of NF-κB and c-Jun was weaker in the CR1 induction group than in control. In contrast, caspase-8 and caspase-3 expression was higher in the CR1 induction group. Furthermore, the number of apoptotic cells was significantly greater in tumors that appeared after injections of both types of CR1-overexpressing cells than in those of control cancer cells. These results suggest that CR1 induces apoptosis by activating the caspase pathway via binding to TNFR1.

Free Research Field

医歯薬学 外科系臨床医学・産婦人科学

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Published: 2018-03-22  

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