2016 Fiscal Year Final Research Report
Epigenetic regulation of large intergenic non-coding RNA in Head and Neck Cancer
| Project/Area Number |
26462599
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
Misawa Kiyoshi 浜松医科大学, 医学部附属病院, 講師 (90334979)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 頭頸部癌 / DNAメチル化 / SALL4遺伝子 / non-coding RNA / エピジェネティクス |
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| Outline of Final Research Achievements |
This study examined non-coding RNA profiles of head and neck cancer (HNSCC) cell lines by Sal-like protein (SALL)4 siRNA transfection evaluated their significance and value as a biomarker.SALL4 siRNA transfection was associated with transcriptional inhibition of 3.8% lincRNA and was correlated with transcriptionalincrement of 3.6% lincRNA by next-generation sequencing analysis.
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| Free Research Field |
頭頸部癌
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