Elucidating the onset mechanism and establishment of the prophylaxis of peritonsillar abscess

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462609
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Oita University
• Principal Investigator: Watanabe Tetsuo 大分大学, 医学部, 准教授 (50231709)
• Co-Investigator(Kenkyū-buntansha): 鈴木 正志 大分大学, 医学部, 教授 (60211314)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 扁桃周囲膿瘍 / 反復性扁桃炎 / 口蓋扁桃 / サイトカイン

Outline of Final Research Achievements

The purposes of this study are to elucidate onset mechanism of peritonsillar abscess and to help establish preventive strategy of peritonsillar abscess and deep neck infection. We investigated mRNA expression of TLR2, IL-6, TNF-α, ICAM1, CD4, FOXP3, IL-17A and IL17F in palatine tonsils from patients with peritonsillar abscess and recurrent tonsillitis using real time PCR method.
The significant differences were not seen in mRNA expressions between two groups. Many patients with peritonsillar abscess do not have the history of recurrent tonsillitis. Our results suggested that there might be a cause of abscess formation in other than palatine tonsil.

Free Research Field

耳鼻咽喉科学