Metastasis and invasion mechanism in the hypoxia environment of parotid gland cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462616
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Nagoya City University
• Principal Investigator: IJICHI Kei 名古屋市立大学, 大学院医学研究科, 助教 (50510278)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 唾液腺がん / 低酸素 / 悪性化 / HIF-1

Outline of Final Research Achievements

We conducted the study for the purpose of hypoxia environment elucidating a mechanism to promote the malignant transformation of the salivary gland cancer tissue.
Thyroid cancer cell line 8305c, TT and salivary gland cancer cell line A253 and NSDC-5F as a control were cultured in a hypoxia condition, then confirmed expression of HIF-1α in immunoblotting. HIF1α and β were expressed in A253 and NSDC-5F, TT, but was not able to confirm expression in 8305c. We observed a status of the epithelium mesenchyma transition and metastasis related protein in a hyponoxia condition similarly in immunoblotting, but there were no changes of the expression level in a hypoxia condition for TT and A253 where there was expression of HIF-1α.

Free Research Field

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