2016 Fiscal Year Final Research Report
Comprehensive analysis of expressed molecules in mandibular gingival cancer and elucidation of involvement of netrin 1
| Project/Area Number |
26462622
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 歯肉癌 / NKG2Dリガンド / netrin-1 |
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| Outline of Final Research Achievements |
We found that all cases of gingival cancers were positive for MICA/MICB immunostaining. We also showed that netrin-1 inhibits osteoblast differentiation and promotes osteoclast differentiation. These results suggest that MICA/MICB and netrin-1 are involved in the development of tumor and bone destruction, respectively.
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| Free Research Field |
頭頸部癌
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