2016 Fiscal Year Final Research Report
Exploratory study of novel neuroprotective treatment using microglia macrophages
| Project/Area Number |
26462677
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | マイクログリア / マクロファージ / 緑内障 |
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| Outline of Final Research Achievements |
The pathology of glaucoma is thought to be RGC death caused by obstruction of optic nerve axon flow to retinal ganglion cells (RGC). Various inflammatory or anti-inflammatory cytokines / chemokines are involved in the course of RGC death, and these cytokines / chemokines are produced from microglia, mueller cells or macrophages recruited into the retina after injury It is thought that. In this study, we observed microglia / macrophage kinetics at the time of disorder, and it turned out that cells associated with RGC death were macrophages and those with neuroprotective effect to suppress RGC death were microglia.
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| Free Research Field |
眼科学
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