2017 Fiscal Year Final Research Report
Signal transduction of goblet cells differentiation and clinical application
| Project/Area Number |
26462681
|
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
|
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| Research Institution | Nihon University (2016-2017)
The University of Tokyo (2014-2015) |
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Principal Investigator |
|
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| Research Collaborator |
YOKOO Seiichi
|
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| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Keywords | 杯細胞 |
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| Outline of Final Research Achievements |
We tried to investigate the stemness of isolated cells derived from human conjunctival epithelium and intra-and extracellular signal transduction system. Isolated single cells from human donor conjunctival epithelium express conjunctival epithelium-specific markers and show limited self-renewality, suggesting that isolated single cells are precursors derived from human conjunctival epithelium. FGFR is a functional receptor based on the findings of PCR, western blotting, and blocking experiments with monoclonal antibody.
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| Free Research Field |
眼科学
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