2016 Fiscal Year Final Research Report
Development of new drug delivery systems in ophthalmology using bionanosheet
| Project/Area Number |
26462682
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | University of Yamanashi |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | drug delivery system / 緑内障 |
|---|
| Outline of Final Research Achievements |
We developed various types of bionanosheets and investigated the possibility of these for the following subjects; layer-by-layer structured bionanosheet from anion membrane and cation membrane, constructed from poly-lactic acid, and hybrid of these two bionanosheet. We investigated adhesive strength to the ocular tissues and drug releasing profile, of these bionanosheet. We investigated these bionanosheet regarding usefulness and safety in clinically applicable three fields; sustained intraocular reduction, supplemental agent for filtering surgery, and no-suture wound closure.
In conclusions, we confirmed assembled bionanosheet could control reasonable drug release profile, improving filtering surgery results, and close corneal wound without suture.
|
| Free Research Field |
眼科学
|
