Development of neuroprotective treatment for glaucoma with scleral crossing around the optic nerve head

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462686
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Osaka University
• Principal Investigator: Kenji Matsushita 大阪大学, 医学系研究科, 講師 (40437405)
• Co-Investigator(Kenkyū-buntansha): 臼井 審一 大阪大学, 医学部附属病院, その他 (20546882) ; 相馬 剛至 大阪大学, 医学系研究科, 助教 (70582401)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: クロスリンキング / 緑内障 / 紫外線 / 篩状板 / 神経保護

Outline of Final Research Achievements

Glaucoma is now understood as a chronic multifactorial disease which progresses with numerous risk factors such as circulatory disorders other than ocular pressure, vulnerability of lamina cribrosa, heredity, immunity and the like. Particularly attention is paid to the vulnerability of the lamina cribrosa and the tissue around the optic disc that support the optic nerve head. Here, to treat glaucoma, we are developing the cross-linking therapy, which is clinically applied to keratoconus, and attracting attention as a treatment for myopia to the pericapillary sclera. We confirm the effectiveness to biological safety and increase of scleral strength. Furthermore, the efficacy of neuroprotective effect is confirmed with a intra ocular hypertensive model mouse.

Free Research Field

医工学