2016 Fiscal Year Final Research Report
A new strategy targeting microRNAs for cardiac protection against ischemia/reperfusion injury
| Project/Area Number |
26462758
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Oita University |
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Principal Investigator |
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| Research Collaborator |
Saito Shotaro
Nishio Satoru
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | マイクロRNA / 虚血再灌流障害 |
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| Outline of Final Research Achievements |
The present project aims to alleviate cardiac ischemia/reperfusion injury by modulating microRNAs. Reactive oxygen species (ROS) were increased by upregulating microRNA 200c and 141, and decreased by suppressing these microRNAs. We revealed that microRNA 200c and 141 increased ROS level by suppressing the activities of catalase and superoxide dismutase. We conclude that modulating these microRNAs may be a possible target against ischemia/reperfusion injury in the heart.
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| Free Research Field |
循環器内科学
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