Establishment of predictive methods for clinical prognoses at ultra-acute and acute phases after carbon monoxide poisoning

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462764
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Iwate Medical University
• Principal Investigator: Beppu Takaaki 岩手医科大学, 医学部, 教授 (70275543)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 一酸化炭素中毒 / 酸化ストレス / free-radicals / 大脳白質障害 / 慢性神経症状

Outline of Final Research Achievements

We hypothesized that measurements of the extent of oxidative stress and anti-oxidative potential should be able to predict cerebral white matter damages after carbon monoxide (CO) poisoning. As a result, patients who showed more increase of oxidative stress as well as more decrease of anti-oxidative stress suffered severer brain damages afterward. As the another research, we compared chronic symptoms between patients treated with and without free-radical scavenger immediately after CO poisoning. Consequently, patients who were treated with free-radical scavenger tended to show milder symptoms than the other patient group.
These results suggested that internal free-radicals after CO poisoning plays a role of the mediators during the process from CO exposure and brain damage.

Free Research Field

脳神経外科・救急医学