Studies on the relationships between water transportation through alveolar type II epithelial cells (dome formation) and development of pulmonary edema

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462765
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Iwate Medical University
• Principal Investigator: Suwabe Akira 岩手医科大学, 医学部, 教授 (20241713)
• Co-Investigator(Renkei-kenkyūsha): OGASAWARA RIE 岩手医科大学, 医学部, 助教 (70347871)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 肺水腫 / 肺胞II型上皮細胞 / ドーム形成

Outline of Final Research Achievements

Disturbance in water transportation through alveolar type II epithelial cells was suggested to be involved in the development of pulmonary edema. In the present study, we established the in vitro system to evaluate the agents affecting the dome formation which reflects the water transportation through alveolar type II epithelial cells, using our original cell dynamic recording system with a special four-divided chamber. Using our system, it was suggested the agents such as drugs or biological active materials affecting the development of pulmonary edema can be evaluated.

Free Research Field

医歯薬学