ES derived neuronal stem cells ameliorate ischemic brain injury in mice

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462772
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Fujita Health University
• Principal Investigator: Hata Ryuji 藤田保健衛生大学, 医学部, 教授 (90258153)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 脳血管障害 / 神経再生 / ES細胞

Outline of Final Research Achievements

Stroke is the leading cause of disability and the third cause of death in the world. Despite intense investigations, no therapy that prevents stroke-induced brain damage and neurological dysfunction has emerged. Recently a growing number of evidence supports regenerative medicine is working to restore structure and function of damaged brain tissues. In this study, we investigated the effects of transplantation of the neural stem cell derived from ES cells on cerebral ischemia. Consequently we have demonstrated that neural stem cells derived from embryonic stem cells have shown protective effects on ischemic insults. Our results have suggested that stem cell therapy has proven effective in promoting functional recovery and protecting secondary degeneration of the thalamus in animal models of cerebral ischemia and therefore represents a hopeful therapy for this unmet medical condition, although further investigations must be required to clarify their repair mechanisms in the brain.

Free Research Field

神経科学