Roles of fatty acids and fatty acid-binding proteins (FABP) in cartilage resorption

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462796
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Meikai University
• Principal Investigator: AMANO Osamu 明海大学, 歯学部, 教授 (60193025)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 脂肪酸結合タンパク / 軟骨吸収 / 軟骨吸収細胞 / メッケル軟骨 / 骨端板 / セプトクラスト

Outline of Final Research Achievements

We found the expression and localization of epidermal type-fatty acid-binding protein (EFABP) in septoclasts at the osseo-chondral junction of the growth plate in mice. Morphology of the septoclastic process was associated with an activity of the endochondral ossification. As E-FABP has affinity to retinoic acid, septoclasts showed apoptosis or morphological changes via PPAR and CD-RAP against overdose or deficiency of retinoic acid. E-FABP-positive septoclasts were also involved in absorption of the Meckel's cartilage.
This project reveled that septoclasts play important roles in physiological cartilage resorption and they are regulated by signaling pathways via E-FABP-binding fatty acids or retinoic acid.

Free Research Field

口腔解剖学・組織学・発生学