2016 Fiscal Year Final Research Report
Analysis of osteoclast precursor niche regulated by BM-MSC
| Project/Area Number |
26462826
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 破骨細胞 / 破骨細胞前駆細胞 / ニッチ / 間葉系幹細胞 / 骨芽細胞 / Runx2 / Osterix / レプチン受容体 |
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| Outline of Final Research Achievements |
Previously, we identified an in vivo osteoclast precursor (QOP: quiescent osteoclast precursor). We hypothesized that the QOP are regulated by bone marrow mesenchymal stem cells (BM-MSC), and analyzed in vivo behavior of BM-MSC. In the present study, we revealed following things: (1) BM-MSC (LepR+ cells) express Runx2 (LepR+Runx2low cells). (2) In response to parathyroid hormone (PTH), LepR+Runx2low cells differentiate into osteoblasts via milt-layered cell formation. (3) The multi-layered cells express Osterix and Type I collagen sequentially, and eventually differentiate into mature osteoblasts.
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| Free Research Field |
骨代謝学
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