2016 Fiscal Year Final Research Report
Elucidation of the interplay between oral bacteria and intestinal innate immunity using Paneth cells in organoid cultures
| Project/Area Number |
26462831
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 自然免疫 / Paneth細胞 / α-defensin |
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| Outline of Final Research Achievements |
To clarify the relationship between oral bacteria and intestinal epithelia cells in terms of innate immunity, the aim of this study was to establish an evaluation system for intestinal innate immunity focused on Paneth cell α-defensin secretory functions.New analysis method for Paneth cell secretory functions using cultured organoids from mouse small intestine and newly developed sandwich ELISA for α-defensin were established.
These methods will contribute to clarifying links between oral bacteria and intestinal innate immunity.
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| Free Research Field |
自然免疫
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