2016 Fiscal Year Final Research Report
Role of formation of necrotic layer by the pulp capping agents pasting
| Project/Area Number |
26462890
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Kyushu Dental College (2016)
Kagoshima University (2014-2015) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | アラーミン / 象牙芽細胞 / 石灰化 |
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| Outline of Final Research Achievements |
In this study, when HMGB-1 which is one of Alarmin was directly administered to mouse odontoblast cells, mineralization of odontoblasts was not confirmed.Then, dental pulp cells of rats were primarily cultured, HMGB-1 was administered to this medium, the culture supernatant was collected, and the culture supernatant was added to the culture medium of the strain cells of the odontoblast lineage However, proliferation and mineralization of odontoblasts was observed.
From the above results, it was suggested that there exist cells in the pulp in response to alarmin to give calcification factor of odontoblasts.
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| Free Research Field |
歯科保存学
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