2016 Fiscal Year Final Research Report
Approach to osseointegration based on the cytoskeletal regulation by implant
| Project/Area Number |
26462924
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | インプラント / 表面形状 / 細胞骨格 |
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| Outline of Final Research Achievements |
Cytoskeletal regulation and its related-cellular functions by implant surface topography (Smooth (S), Micron (M) and Nano (N) surfaces) were investigated. S-adherent cells exhibited cell spreading and M- and N-adherent cells had longer ans thinner projections. RhoA, a cytoskeletal regulatory factor, was activated in order of surface roughness. Longer and thinner projections were induced by RhoA inhibitor on all surfaces. Although RhoA inhibitor altered cellular functions (adhesion, migration and differentiation into osteoblast) on S surface, these were limited on M and N surface. These findings suggest regulation of cellular functions by surface topography is associated with cytoskeletal regulation.
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| Free Research Field |
歯科補綴学
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