2016 Fiscal Year Final Research Report
Qualitative analysis of the activated bone metabolism in bone regeneration with the cultured autogenous periosteal cell grafting by high quality 3D-CT image analysis
| Project/Area Number |
26462967
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 培養骨膜細胞 / 歯科インプラント / 骨再生 / 3D-CT / 画像解析 / 骨代謝 |
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| Outline of Final Research Achievements |
Purpose: Evaluation of the effect of cultured autogenous periosteal cells (CAPC) on sinus lift (SL). Materials and Methods: SL with autologous bone and PRP plus CAPC [CAPC(+)SL] was performed in 23 cases. Pieces of mandibular periosteum were cultured in M199 medium with 10% FBS for 6 weeks. As control, 16 cases received SL with autologous bone and PRP [CAPC(-)SL]. High-resolution 3D-CT was performed before, 4 months and 1 year after SL, and stratified data based on CT numbers corresponding to soft tissue, cancellous bone, and cortical bone were subject to analysis. Results: CAPC(+)SL revealed an increase in CT numbers corresponding to cancellous bone as well as a decrease in those to cortical bone. CT numbers corresponding to cancellous bone were increased in CAPC(+)SL while they were decreased in CAPC(-)SL. Implant insertion torque was significantly higher in CAPC(+)SL. Conclusion: By promoting bone anabolic activity, CAPC is expected to aid osseointegration in clinical applications.
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| Free Research Field |
再生医療
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