2016 Fiscal Year Final Research Report
Stem cells for bone regeneration in the jaw bone
| Project/Area Number |
26462990
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
Tei Kanchu 北海道大学, 歯学研究科, 教授 (80180066)
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 歯学 / 間葉系幹細胞 |
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| Outline of Final Research Achievements |
This study aimed to demonstrate the usefulness of bone marrow derived mesenchymal stem cells (MSCs) in jaw bone reconstruction.In transplant experiments in mice, we demonstrated that transplantation of MSCs and HSCs led to the induction of bone formation and contributed to the replacement of carriers in the grafts by bone tissue.It was suggested that HSCs in the graft enhance bone formation from MSCs by sending multiple signals to MSCs.In this study, we were able to obtain important cell biological findings on the mechanism underlying the differentiation of MSCs.
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| Free Research Field |
口腔外科学
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