2016 Fiscal Year Final Research Report
Study on target of cancer immunoediting in oral cancer
| Project/Area Number |
26462992
|
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Hirosaki University |
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Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 口腔癌 |
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| Outline of Final Research Achievements |
Little report regarding immunotherapy for oral cancer has been shown. Since Oral immune tolerance has been proposed, we focused on the effect of innate immune system-associated factors in ant-tumor effect in oral cancer. We initially generated Fucci-expressing oral cancer cell line to evaluate cell cycle. Using this cell line, we found that little individual immune-related factor altered cell cycle distribution in response to anticancer reagents. However, we also observed that multiple immune-related factors did affect the cell cycle distribution altered by the anticancer drugs, indicating that immune-related factors may alter the anticancer effect in oral cancer.
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| Free Research Field |
口腔外科
|
