2016 Fiscal Year Final Research Report
Functional analysis of GSK3beta in human oral cancer stem cells
| Project/Area Number |
26463005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
Shigeishi Hideo 広島大学, 医歯薬保健学研究院(歯), 助教 (90397943)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 口腔癌 / 癌幹細胞 |
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| Outline of Final Research Achievements |
CD44 and aldehyde dehydrogenase 1 (ALDH1) has been proved useful marker for the identification of cancer stem cells (CSCs). We previously reported that glycogen synthase kinase 3(GSK3beta) is involved in the regulation of self-renewal ability of oral squamous cell carcinoma (OSCC) CSC (Shigeishi et al. 2013). We demonstrate that GSK3beta play a major role in the maintenance of stemness of CD44high/ALDH1high HNSCC cells. Additionally, our results indicate a close relationship between CSC and mesenchymal character in OSCC.
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| Free Research Field |
口腔外科学
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