2016 Fiscal Year Final Research Report
Function of Heme oxygenase-1 induced from oral mucosal cells and the role for oral candidiasis
| Project/Area Number |
26463007
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
Kouji Ohta 広島大学, 病院(歯), 助教 (20335681)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | ヘムオキシゲナーゼ1 (HO-1) / 口腔粘膜細胞 / 口腔カンジダ症 |
|---|
| Outline of Final Research Achievements |
Oral mucosa may regulate stress response against Candida. We focused on Heme oxygenase-1 (HO-1) gene induced by Candida albicans (Ca), and investigated the HO-1 expression oral keratinocytes. We found HO-1 expression induced by heat-killed Ca using a cDNA microarray. beta-glucan derived from Ca increased HO-1 expression in oral keratinocytes. beta-glucans promoted induction of intercellular reactive oxygen species and Nrf2 translocation into nuclei. HO-1 induced by beta-glucan may have an important role in host defense against the stress caused by C. albicans.
|
| Free Research Field |
口腔外科
|
