2016 Fiscal Year Final Research Report
Development and clinical application of the bone scintigraphy quantitative evaluation system for oral and maxillofacial diseases
| Project/Area Number |
26463011
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 骨シンチグラフィ / 定量化 / 口腔外科疾患 / Bone Uptake Value（BUV） |
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| Outline of Final Research Achievements |
Our primary objectives were to (1) develop a quantitative analysis of bone scintigraphy images for various oral surgical diseases and (2) improve the accuracy of the diagnosis and evaluation of oral surgical diseases. We quantified bone scintigraphy images using a value we termed the 'bone uptake value (BUV),' calculated as the bone accumulation of radiopharmaceuticals, by correcting each pixel value of bone scintigraphy. The results of this quantification demonstrated that a long-term administration of bisphosphonate, one of the causative agents of antiresorptive agent-related osteonecrosis of the jaw (ARONJ), increases the bone metabolic activity of the jaw. Our present findings indicate that the quantitative analysis of bone scintigraphy images described herein can be used to elucidate the mechanism underlying the occurrence of ARONJ. Our results also clarify that results of this quantitative analysis would be useful as a predictor and an indicator of the treatment course of ARONJ.
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| Free Research Field |
口腔外科
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