2016 Fiscal Year Final Research Report
A study of immune cell network involved in pathogenesis of oral lichen planus
| Project/Area Number |
26463013
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 口腔扁平苔癬 / サイトカイン / T細胞 |
|---|
| Outline of Final Research Achievements |
Helper T (Th) 1, Th 2 of oral lichen planus (OLP) are pay attention to Th 17 and regulatory T cells (Treg) which have recently been reported to be associated with pathogenesis in autoimmune diseases and chronic inflammatory diseases. We also performed to research on those Th subsets.
Expression of Th1, Th2 and Th17 type related molecules was enhanced in OLP patients compared with healthy subjects. In addition to the basal layer with marked hyperkeratosis, IL-23 showed to express in all epithelial layers and lymphocytes immediately beneath the epithelium. Also, expression of Th2 type IL-33 was found in the basal layer of the mucosa. TSLP as Th2-related molecule was identified and expression was found in the basal layer of the mucosa. And so, we published the result of the research.
|
| Free Research Field |
口腔外科
|
