The analysis of the role of CCN3 in the formation of vascularization at the tissue regeneration and the constraction of the drug discovery

2016 Fiscal Year Final Research Report

• Project/Area Number: 26463017
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Nagasaki University
• Principal Investigator: MINAMIZATO Tokutaro 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (50529807)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 再生医療

Outline of Final Research Achievements

Several lines of evidence have demonstrated that the CCN family of proteins regulates differentiation of the skeletalmesenchymal cells such as muscle cells, chondrocytes and osteoblasts. In this research, for the purpose of the anlysis of function of CCN3 in the formation of vascularization in tissue regeneration, we focus on the interation between CCN3 and VEGF, CD34 cells, especially. As the results, we verified that CCN3 controled the formation of new vascularization by binding to the VEGF which is secreted protein, experimentally. In addition, we demonstratd that the CCN3-Notch pathway also regulate the new vascularization, indirectly.

Free Research Field

口腔外科学