2016 Fiscal Year Final Research Report
The analysis of the invasion mechanism of oral squamous cell carcinoma induced by new EMT-related gene MTDH
| Project/Area Number |
26463043
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
Ono Shigehiro 広島大学, 医歯薬保健学研究院(歯), 助教 (70379882)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 口腔癌 / 高度浸能 |
|---|
| Outline of Final Research Achievements |
We studied for the purpose of clarifying the details of the mechanism of EMT which gave to the acquisition of high invasive ability of oral squamous cell carcinoma that Metadherin (MTDH) which we found induced.We investigated in detail a cell motility, an overexpression of the substrate degrading enzyme and a decreased expression of cell adhesion factor we have researched and examined ever.These results suggest that MTDH may relate with the acquisition of high infiltration ability of the oral squamous cell carcinoma cell.In addition, it was suggested that the acquisition of infilitration ability can relate to the acquisition of the stem cell-like form closely.
|
| Free Research Field |
口腔外科学
|
