Development of the new therapeutic strategy for recurrence/metastatic oral cancer -toward natural life with oral cancer-

2016 Fiscal Year Final Research Report

• Project/Area Number: 26463045
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Yamaguchi University
• Principal Investigator: UEYAMA Yoshiya 山口大学, 医学(系)研究科(研究院), 教授 (00168668)
• Research Collaborator: FERDOUS Tarannum 山口大学, 大学院医学系研究科, 学術研究員 (70647932)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 癌幹細胞 / リプログラミング / iPS / エピソーマルベクター / IPA / スルファサラジン

Outline of Final Research Achievements

We made a comparison between the artificial cancer stem cells obtained by the induction of cellular reprogramming and the parental cells by microarray analysis. The expression of the factors related to the malfunction of mitochondria and the morphological or metabolic aberration of cell was increased in the artificial cancer stem cells. However, we could not find the new important factors associated to the artificial cancer stem cells. Also, we found sulfasalazine, medicine for ulcerous colitis or articular rheumatism was effective for the artificial cancer stem cells though they exhibited increased resistance to chemotherapeutic agents, molecular targeting agents and radiation. Our findings suggested that the new therapeutic strategy with sulfasalazine may be effective for recurrence/metastatic oral cancers through the regulation of oral cancer stem cells.

Free Research Field

口腔癌