Distinction and analysis of the distant metastasis marker in oral squamous cell carcinoma.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26463049
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kumamoto University
• Principal Investigator: TANAKA TAKUYA 熊本大学, 医学部附属病院, 診療助手 (30631767)
• Co-Investigator(Renkei-kenkyūsha): MASANORI Shinohara 熊本大学, 医学部附属病院, 非常勤診療医師 (90117127)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 転移 / Angptl4

Outline of Final Research Achievements

Background: Angptl4 is a critical mediator and promotes trans-endothelial migration of cancer cells．We found a marked increase of Angptl4 mRNA in tongue cancer cells that metastasized into the lung (Tanaka et al, Int. J. Oncol. 2016). Thus, we investigated a relationship between tongue cancer cell Angptl4 expression and clinicopathological parameters of the patients. Methods: Immunohistochemical staining for Angptl4 was performed for tongue cancer tissues from patients who had radical surgery but not pre-operative therapies. Twenty patients with metastasis and 20 patients without metastasis were enrolled. Results: By Kaplan-Meier method, Angptl4-positive patients showed significantly shorter overall survival and recurrence-free survival than Angptl4-negative patients. Conclusion: Angptl4 is likely associated with tongue cancer progression and its expression of the cancer cells may be predictive of poor prognosis of the patients. Thus, Angptl4 is a possible therapeutic target.

Free Research Field

口腔癌転移マーカー